蛋白质巯基亚硝基化(S-nitrosylation,SNO)是指一氧化氮(NO)对蛋白质的半胱氨酸残基进行可逆性氧化还原修饰,这种修饰是NO在体内发挥作用的重要途径之一。近年来研究表明蛋白质SNO可以参与多种生理和病理过程,特别是一些靶蛋白的SNO参与神经退行性疾病发病过程及相关机制的研究倍受关注,该文对这方面近期研究进行概述。 Protein S-nitrosylation (SNO) refers to the irreversible redox modification of protein cysteine ​​residues by nitric oxide (NO), an important pathway by which NO plays a role in the body one. In recent years, studies have shown that protein SNO can participate in a variety of physiological and pathological processes, in particular, some target protein SNO involved in the pathogenesis of neurodegenerative diseases and related mechanisms of much concern, this article is an overview of recent research.