Objective To analyze the influence on the functions of the sacral nerves after curettage and local pouring chemotherapy and radiotherapy by the approach in anterior with posterior to treat the high sacral tumors. Methods 24 cases, include their oncology results and functions of the sacral nerves were analyzed. Results Average follow up 56 months, 3 malignant cases were died of the tumor metastasis. 4 recurrent cases were recurred after treatment between 13 to 32 months. For the tumor curettage demand, the one side S2 nerve of 2 cases and the S2, 3 nerve of 1 case were cut off. The other cases sacral nerves were reserved completely. Conclusions This treatment method by local chemotherapy and radiotherapy to treat the high sacral tumors was not influence on the functions of the sacral nerves.