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粘液性水肿被认为是某些呼吸系统功能障碍的原因。作者报告3例严重的粘液性水肿表现为睡眠梗阻性呼吸暂停。例1,58岁,男。1年前始有体重增加,白天高度嗜睡,每当不活动时,很快入睡。每晚醒5～6次经常醒时出汗,入睡时有响亮的鼾声,体重130.5kg,入院前几个月出现面部和四肢水肿,经内分泌检查证实为原发性甲状腺功能低下。晚上睡眠检查发现多次上呼吸道梗阻,有时长达30sec。动脉氧分压(PaO_2)最低为35mmHg,动脉二氧化碳分压(PaCO_2)最高为53mmHg,伴窦性停搏和心动徐缓。给患者行气管切开和 L-甲状腺素治疗,逐渐增加剂量直到每日口服200μg,于治疗1和8个月复查,睡眠梗阻性呼
Myxedema is considered to be responsible for some respiratory dysfunction. The authors report 3 cases of severe myxedema manifested as sleep apnea. Example 1,58 years old, male. A year ago before the weight gain, a high degree of drowsiness during the day, whenever not active, quickly fall asleep. Wake up 5 to 6 times a night often wake up when sweating, when falling asleep loud snoring, weight 130.5kg, a few months before admission facial and limb edema, endocrine examination confirmed primary hypothyroidism. Night sleep examination found multiple upper airway obstruction, sometimes up to 30sec. Arterial oxygen partial pressure (PaO_2) minimum 35mmHg, arterial carbon dioxide partial pressure (PaCO_2) up to 53mmHg, with sinus arrest and bradycardia. Patients were tracheotomized and treated with L-thyroxine, gradually increasing their dosage until oral administration of 200 μg orally daily for 1 and 8 months of treatment, and obstructive sleep apnea