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目的研究与分析中药注射剂毒性和不良反应,以提高临床用药的安全性。方法选取我院2014年5月-2016年4月期间采用中药注射剂治疗发生不良反应的65例患者作为研究对象,回顾性分析所有患者的临床资料。对本组65例发生不良反应患者的年龄因素、使用药物种类、器官损伤以及不良反应具体表现等进行分析。结果本组65例患者中,60岁以上的患者36例,所占比例为55.38%;其中脉络宁、血塞通以及喜炎平所引起的不良反应较多,分别占29.23%、21.54%、18.46%;中药注射剂所造成的不良反应主要是对皮肤及其附件的损害,临床主要表现为皮疹、皮肤瘙痒以及面色潮红等,其次是循环系统的损害,临床主要表现为心悸、静脉炎等。结论中药注射剂在临床中的应用越来越广,且引起的不良反应危害较大,在临床中需严格使用,特别是老年群体,使用中药注射剂后需对其不良反应进行严密监测,以减少中药注射剂的毒性,并降低不良反应发生率。
Objective To study and analyze the toxicity and adverse reactions of traditional Chinese medicine injection in order to improve the safety of clinical medication. Methods Sixty-five patients with adverse reactions treated with traditional Chinese medicine injections in our hospital from May 2014 to April 2016 were selected as the research object, and the clinical data of all patients were retrospectively analyzed. This group of 65 patients with adverse reactions in patients with age factors, the use of drug types, organ damage and adverse reactions, such as specific performance analysis. Results Among the 65 patients in our study, 36 cases were over 60 years old, accounting for 55.38% of the total. Among them, Mailuoning, Xuesaitong and Xiyanping had more adverse reactions, accounting for 29.23%, 21.54% 18.46%. The adverse reactions caused by traditional Chinese medicine injections are mainly the damage to the skin and its appendages. The main clinical manifestations are rash, pruritus and flushing, followed by the damage of the circulatory system. The clinical manifestations include palpitations and phlebitis. Conclusion Traditional Chinese medicine injection in the clinical application of more and more widely, and the adverse reactions caused by greater harm, to be strictly used in clinical practice, especially the elderly population, the use of Chinese medicine injection after adverse reactions to be closely monitored to reduce traditional Chinese medicine Injection toxicity, and reduce the incidence of adverse reactions.