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弥漫性大B细胞淋巴瘤(DLBCL)作为非霍奇金淋巴瘤(NHL)中最常见的一种亚型,在过去的10年里,其发病率明显增加,越来越成为人们关注的重点。作为一组在形态学、生物学行为和临床上具有显著异质性的恶性肿瘤,DLBCL的病因学及发病机制复杂。多年来,病毒感染与DLBCL的关系一直成为人们关注的焦点之一。现主要讨论Epstein-Barr病毒、人类获得性免疫缺陷病毒、乙型肝炎病毒、丙型肝炎病毒及人类T淋巴细胞/白血病病毒1型-1感染相关性DLBCL的临床及免疫学特点。
As the most common subtypes of non-Hodgkin’s lymphoma (NHL), diffuse large B-cell lymphoma (DLBCL) has been the focus of increasing attention in the past decade . As a group of morphologically, biologically and clinically significant heterogeneity of malignant tumors, the etiology and pathogenesis of DLBCL are complex. Over the years, the relationship between viral infection and DLBCL has been one of the focuses of attention. The clinical and immunological features of DLBCL associated with Epstein-Barr virus, human acquired immunodeficiency virus, hepatitis B virus, hepatitis C virus and human T-lymphocyte / leukemia virus type 1-1 infection are now discussed.