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以辐射热甩尾法的甩尾潜伏期作为痛阈，观察纳洛酮（ＮＡＬ）对伏核注入精氨酸加压素（ＡＶＰ）能提高痛阈及增强电针镇痛作用的影响。结果：伏核内微量注入ＡＶＰ（０．０１５Ｕ），大鼠痛阈提高，针刺镇痛效应明显增强。伏核预先注入ＮＡＬ（０．８μｇ），明显削弱ＡＶＰ的镇痛和增强电针镇痛作用。１、２、３Ｖ电针的平均针效与对照组比较减弱了３７％（Ｐ＜０．０１），电针后效由４０ｍｉｎ缩短为２０ｍｉｎ。结果表明，ＡＶＰ参与痛觉调节过程，并在电针镇痛过程中发挥一定的作用。这种作用部分是由内源性阿片肽系统中介的。
To investigate the effect of naloxone (NAL) on vomiting of arginine vasopressin (AVP) can increase the pain threshold and enhance the analgesic effect of electroacupuncture. Results: Microinjection of AVP (0.015U) into the nucleus accumbens increased the pain threshold and markedly enhanced the acupuncture analgesia. Nerve nucleus pre-injected with NAL (0.8μg), significantly weakened the AVP analgesia and enhance the role of electroacupuncture analgesia. The average acupuncture efficacy of 1,2,3 V electroacupuncture was 37% lower than that of the control group (P <0.01), and the post-electroacupuncture efficacy was shortened from 40 min to 20 min. The results showed that AVP participates in the process of pain regulation and plays a role in the electroacupuncture analgesia. This effect is mediated in part by the endogenous opioid system.