树突状细胞(Dendritic cell,DC)是来源于骨髓的专职抗原递呈细胞,具有启动T细胞介导的免疫反应功能,因其表面有众多树突状突起而得名。DC于1973年由Steinman和Cohn首先发现,近年研究表明DC与肿瘤患者的免疫功能密切相关。本文就其近年研究进展作一综述。 1 树突状细胞表型的研究人DC表达甘露糖/岩藻糖膜植物血凝素,通过此糖受体可特异结合并内吞甘露糖/岩藻糖为末端糖蛋白,参与病原体的非特异性吞噬。体外实验中,CD1a~+的DC可内吞糖 Dendritic cells (DCs) are full-time antigen-presenting cells derived from the bone marrow. They are capable of initiating T cell-mediated immune responses and are named after numerous dendrites on the surface. DC was first discovered by Steinman and Cohn in 1973. Recent studies show that DC is closely related to the immune function of cancer patients. This article reviews recent progress in its research. 1 Dendritic Cell Phenotypes Human DCs express mannose / fucose membrane phytohemagglutinins, which specifically bind to and endocytose mannose / fucose as terminal glycoproteins through this sugar receptor, Heterosexual engulfing. In vitro experiments, CD1a ~ + DC can endocytose