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目的探讨紫杉醇化疗同步放射治疗食管癌气管食管沟淋巴结转移的近期疗效。方法 51例的食管癌气管食管沟淋巴结转移患者按治疗方法不同分为治疗组(25例)和对照组(26例)。治疗组行三维适形放疗,同时每周接受1次紫杉醇30mg化疗,连用5～6周;对照组行单纯放疗。两组放疗均采用常规分割,总剂量60Gy。结果治疗组与对照组局部控制率(CR+PR)分别为88%(22/25)和50%(13/26),1年生存率分别为80%(20/25)和34.6%(9/26),2年生存率分别为44%(11/25)和11.5%(3/26)差异有统计学意义。不良反应主要表现为放射性食管炎和白细胞下降,多为Ⅰ、Ⅱ级。结论紫杉醇化疗联合三维适形放疗治疗食管癌气管食管沟淋巴结转移可提高局部控制率和近期疗效,副作用可耐受
Objective To investigate the short-term efficacy of paclitaxel-based chemotherapy in simultaneous radiotherapy for esophageal tracheo-alveolar lymph node metastasis. Methods Fifty-one cases of esophageal cancer with esophageal sulcus lymph node metastasis were divided into treatment group (25 cases) and control group (26 cases) according to different treatment methods. The treatment group underwent three-dimensional conformal radiotherapy, and received one week of paclitaxel 30 mg chemotherapy once a week for 5 to 6 weeks. The control group received radiotherapy alone. Both groups of radiotherapy were routinely divided and the total dose was 60 Gy. Results The local control rate (CR+PR) was 88% (22/25) and 50% (13/26) in the treatment and control groups, respectively. The 1-year survival rates were 80% (20/25) and 34.6% (9). /26), the 2-year survival rate was 44% (11/25) and 11.5% (3/26) were statistically significant. The main adverse reactions were radiation esophagitis and leukopenia, mostly grades I and II. Conclusion Paclitaxel chemotherapy combined with three-dimensional conformal radiotherapy for the treatment of esophageal cancer tracheogastric lymph node metastases can improve local control rate and short-term efficacy, and side effects can be tolerated