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目的 :研究苯那普利对实验性大鼠的胰岛素抵抗 ( ISR)的影响。方法 :选择雄性 SD大鼠饲以高蔗糖高盐饲料 4周后 ,用苯那普利 ( 3mg· kg-1· d-1,n =9;10 mg· kg-1· d-1,n =9)或安慰剂 ( n =10 )治疗 4周。另一组饲以高蔗糖高盐大鼠 ( SSFR) ( n =9)开始即用苯那普利 ( 10 mg· kg-1· d-1)治疗 4周。采用持续输注葡萄糖 ( 8mg· kg-1· min-1)和胰岛素 ( 2 .5 mu· kg-1·min-1)的血糖平均值 ( SSPG)方法测定胰岛素敏感性。观察空腹血胰岛素、血糖、甘油三酯、SSPG的变化。结果 :SSFR大鼠 4周时收缩压明显升高〔( 14 8.4± 18.8) mm Hg:( 12 5 .5± 13.2 ) mm Hg,P<0 .0 5 ( 1mm Hg=0 .133k Pa)〕;SSPG明显升高〔( 10 .80± 2 .39) mmol/ L:( 6.80± 1.38) mmol/ L,P <0 .0 5〕。表明大鼠产生高血压和 ISR。而同时用苯那普利治疗组 ,血压及 SSPG无明显升高。饲以高糖高盐 4周后用苯那普利 3mg· kg-1· d-1治疗组和 10 mg· kg-1· d-1治疗组 ,SSPG由( 11.2 0± 2 .32 ) mmol/ L分别下降至 ( 8.49± 2 .85 ) mmol/ L ( P <0 .0 5 )和 ( 7.45± 1.5 0 ) mmol/ L (P <0 .0 1)。结论 :苯那普利预防治疗 4周 ,大鼠未产生 ISR,苯那普利治疗能改善高糖高盐饲养大鼠的 ISR。
Objective: To study the effect of benazepril on insulin resistance (ISR) in experimental rats. Methods: Male SD rats were fed with high-sucrose and high-salt diet for 4 weeks, then treated with benazepril (3 mg · kg -1 · d -1, n = 9, 10 mg · kg -1 · d -1, n = 9) or placebo (n = 10) for 4 weeks. The other group was treated with benazepril (10 mg · kg-1 · d-1) for 4 weeks starting with high sucrose high salt rat (SSFR) (n = 9). Insulin sensitivity was measured using the mean blood glucose (SSPG) method of continuous infusion of glucose (8 mg · kg -1 · min -1) and insulin (2.5 mu · kg -1 · min -1). Observe fasting blood insulin, blood glucose, triglycerides, SSPG changes. Results: At 4 weeks, systolic blood pressure increased significantly in SSFR rats 〔(14 8.4 ± 18.8) mm Hg: (125.5 ± 13.2) mm Hg, P <0.05 (1mm Hg = 0.133k Pa〕〕 ; SSPG was significantly higher 〔(10 .80 ± 2.39) mmol / L :( 6.80 ± 1.38) mmol / L, P <0.05〕. It shows that rats produce high blood pressure and ISR. At the same time with benazepril treatment group, no significant increase in blood pressure and SSPG. After 4 weeks of treatment with benazepril and 10 mg · kg-1 · d-1 of benazepril, the SSPG increased from (11.2 ± 2.32) mmol / L decreased to (8.49 ± 2.85) mmol / L (P <0.05) and (7.45 ± 1.5) mmol / L (P <0.01) respectively. Conclusion: After benazepril is prophylactically treated for 4 weeks, ISR is not produced in rats. Benazepril treatment improves the ISR in rats fed high glucose and salt diet.