小鼠受超致死剂量全身中子-γ线照射后,由于小肠隐窝细胞对辐射高度敏感,在受照射后数小时内就可观察到隐窝细胞分裂减少或停止,隐窝萎缩,绒毛脱落等。有人将大剂量照射后3—5天内发生的动物早期死亡与射线引起的早期胃肠损伤相联系,并称之为“胃肠型死亡”。隐窝干细胞是小肠隐窝存活、增生的基础,隐窝干细胞具有较强的亚致死损伤修复能力,因而在一定剂量范围内辐射损伤后隐窝数量很快增加,促 After the mice were exposed to a sublethal dose of whole body neutron-gamma rays, as the crypt cells of the small intestine were highly sensitive to radiation, crypt cell division was reduced or stopped within a few hours after irradiation, atrophy of the crypts, shedding of villi Wait. Early animal deaths, which occurred 3-5 days after high-dose irradiation, were linked to early gastrointestinal damage caused by radiation and were referred to as “gastrointestinal death.” Cryptic stem cells are the basis of survival and proliferation of small intestine crypts. Cryptic stem cells have a strong ability of repairing sublethal damage, so the number of crypts increases rapidly after radiation damage within a certain dose range.