用人食管癌组织直接接种于裸鼠,建立两株裸鼠移植瘤株,分别命名为人食管鳞状细胞癌裸鼠移植瘤(HEC_2)和人食管腺鳞癌裸鼠移植瘤(HEC_6),两瘤株的鼠间传代达40余代,历时3年,生长稳定,潜伏期短,移值成功率达100％。并应用于抗癌药物和放射增敏的实验研究,结果表明:平阳霉素对HEC_6有明显的抑制作用,重复两次,抑制率分别为56.5％和8.87％;血卟啉衍生物(HPD)对HEC_2 X线分次照射有明显增敏作用。 Two nude mice transplanted with human esophageal cancer tissue were inoculated directly into nude mice and named as human esophageal squamous cell carcinoma xenograft (HEC_2) and human esophageal adenosquamous carcinoma nude mouse xenograft (HEC_6). The rats of the strain passed through more than 40 generations and lasted for 3 years. The growth was stable, the incubation period was short, and the success rate of transfer was 100%. And applied to anticancer drugs and radiosensitization experimental study, the results show that: Pingyangmycin has a significant inhibitory effect on HEC_6, repeated twice, the inhibition rate was 56.5% and 8.87%; hematoporphyrin derivative (HPD) The X-ray fractionation of HEC_2 has obvious sensitizing effect.