论文部分内容阅读
已经确定视黄素酸(维生素A酸)1对致癌物诱导的小鼠皮肤乳头状瘤和癌具有预防及治疗作用。但实验和临床应用时同时出现的维生素A过多症这一中毒综合征却是一个限制因素。对该分子作广泛的化学修饰后,发现芳香族类视黄素的治疗比可降到1/10,所谓治疗比即乳头状瘤消退和维生素A过多症这两者分离程度的一个判断标准。此外,治疗剂量也可能降低到1/10以下(表1,化合物2)。以2口服治疗角质化皮肤病,特别是牛皮癣,以及几种癌前期病变,已证明上述动物
It has been determined that retinoic acid (vitamin A acid) 1 has a preventive and therapeutic effect on carcinogen-induced mouse dermal papilloma and cancer. However, experimental and clinical application of vitamin A syndrome at the same time the poisoning syndrome is a limiting factor. After extensive chemical modification of the molecule, it has been found that the therapeutic ratio of aromatics to retinoids can be reduced to one-tenth of that of so-called treatment, ie, the degree of separation of both papilloma and vitamin A hyperactivity . In addition, the therapeutic dose may also be reduced to less than 1/10 (Table 1, Compound 2). Oral treatment of keratinized skin diseases, especially psoriasis, and several precancerous lesions have demonstrated that the above animals