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Objective: To investigate the expression of platelet-derived endothelial growth factor (PDGF) and its effect in angiogenesis in endometrial cancer (EC), in order to investigate the mechanism of tumorigenesis and lay a foundation for the management of EC. Methods: We selected 40 cases with EC, 20 endometrium, and 20 normal endometrium. All specimens were stained immunohistochemically for CD34 and PDGF identified immunohistochemically with specific antibodies. Results: The expression of PDGF was significantly higher in EC than normal endometrium and atypical hyperplasia of endometrium (P 0.05). The expression of PDGF was lower in well differentiated than moderately and poorly differentiated EC (P < 0.05). In cases with muscular invasion tumors, it was higher than in normal endometrium (P < 0.05). After Spearman correlation analysis, MVD was significantly influenced by PDGF, r = 0.848 (P = 0.000). Conclusion: There was positive correlation between microvessel density (MVD) and PDGF in earlier stage of EC, it illustrate that PDGF may take part in angiogenesis of EC.