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暴发性肝炎指急性肝炎伴肝性脑病。本文报告6例并用异烟肼与利福平所致的暴发性肝炎,讨论其发生机理与促发因素。 6例有下列共同特征:①用药至黄疸出现为6～10天;②发生黄疽后3天内,出现意识障碍;③血清转氨酶为正常上限的26～80倍;④肝脏主要病变是小叶中央坏死;⑤没有变态反应的表现:⑥6例全都愈复。有理由认为暴发性肝炎的发生与应用这两种药物有关。6例患者原先都没有肝病,乙型肝炎抗原及抗体均阴性。虽然其中4例于黄疸发生前7～10天在全麻下手术,2例曾用过卤烷(Halothane),但所患并不是卤烷性肝炎。因为:(1)他们以往未用过该药,而第一次用药的肝炎的发生率是很低的(约1:10000);(2)缺乏卤烷性肝炎有关的表现,如发热、皮疹、嗜
Fulminant hepatitis refers to acute hepatitis with hepatic encephalopathy. This article reports 6 cases and with isoniazid and rifampin-induced fulminant hepatitis, to discuss the mechanism of its occurrence and trigger factors. 6 cases had the following common features: ① medication to jaundice appeared for 6 to 10 days; ② occurred within 3 days after jaundice, disturbance of consciousness; ③ serum aminotransferase 26 to 80 times the upper limit of normal; ④ liver major lesion is lobular central necrosis ; ⑤ no allergic manifestations: ⑥ 6 cases all the more complex. Reason to think that the occurrence of fulminant hepatitis and the application of these two drugs. Six patients had no previous liver disease, hepatitis B antigen and antibody were negative. Although four of them underwent surgery under general anesthesia 7 to 10 days before jaundice, and two had used Halothane, they did not suffer from Halonella. Because: (1) they have not used the drug in the past, and the incidence of first-time use of hepatitis is very low (about 1: 10000); (2) the lack of Halonavir-related manifestations such as fever, rash , Addicted