2例慢性乙型病毒性肝炎男性患者,年龄为40岁和72岁,因肝功能异常给予阿德福韦酯10mg,1次/d,分别于第3年和第2年后出现肾损害。例1SCr166μmol/L,血磷0.69mmol/L;例2患者SCr124μmol/L,血磷0.61mmol/L,尿蛋白(++)。阿德福韦酯减量至10mg,隔日1次。血生化指标逐渐恢复正常。后来例2因HBVDNA升高自行将阿德福韦酯加量至10mg,1次/d。1个月后SCr119μmol/L,遂再次减量,随后肾功能保持正常。 Two male patients with chronic hepatitis B, aged 40 and 72 years, were given adefovir dipivoxil 10 mg once daily because of abnormal liver function, and renal damage occurred at the third year and the second year, respectively. Example 1 SCr166μmol / L, phosphorus 0.69mmol / L; Example 2 patients SCr124μmol / L, phosphorus 0.61mmol / L, urinary protein (++). Adefovir dipivoxil to 10mg, every other day. Blood biochemical indicators gradually returned to normal. Later, 2 cases due to the increase of HBVDNA adefovir dipivoxil to 10mg, 1 / d. After 1 month, SCr119μmol / L, then reduce again, followed by normal renal function.