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众所周知,铅可引起卟啉代谢紊乱、抑制氨基乙酰丙酸脱水酶(ALAD)活性,增加尿δ-氯基乙酰丙酸(ALA)的排泄。近来研究发现,狨暴露铅后,尿中β-氨基异丁酸(ABA)排泄增多。ABA是胸腺嘧啶的一种正常降解产物,ABA排泄增加,表明铅可能影响胸腺嘧啶的代谢。这一发现将提供用一种新方法评价铅暴露对健康的影响。本研究比较了铅暴露小鼠ABA和ALA在尿中的排泄,同时还观察了铅对小鼠肝脏和肾脏氨基乙酰丙酸合成酶(ALAS)和ALAD的抑制作用。雄性小鼠通过饮用含铅水500 mg/L的方式暴露铅共14 d,
It is well-known that lead can cause disorder of porphyrin metabolism, inhibit the activity of aminolevulinic acid dehydratase (ALAD) and increase urinary excretion of δ-chloro levulinic acid (ALA). Recent studies have found that 狨 exposed lead, urinary β-amino-butyric acid (ABA) increased excretion. ABA is a normal degradation product of thymine, and ABA excretion increases, indicating that lead may affect thymine metabolism. This finding will provide a new way to assess the health effects of lead exposure. This study compared the excretion of urinary excretion of ABA and ALA in lead-exposed mice and the inhibitory effects of lead on aminolevulinic acid synthase (ALAS) and ALAD in mice liver and kidney. Male mice exposed to lead for 14 days by drinking 500 mg / L lead-containing water,