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目的了解福建省AIDS患者接受抗病毒治疗后病毒学抑制效果,分析流行病学特征,为提高治疗效果提供依据。方法对福建省接受抗病毒治疗≥6个月的AIDS患者采集血样并开展HIV-1病毒载量检测,同时通过全国AIDS综合防治管理信息系统收集流行病学资料,分析其流行病学特征。结果共检测血样3 008份,其中病毒有效抑制2 708份,抑制率90.0%;不同地区和治疗时间的病毒抑制效果有差异,福州、厦门、宁德地区患者病毒抑制效果较好;治疗时间≥24个月者病毒抑制效果较好。病毒载量未有效抑制的以男性、已婚或同居、异性传播、临床ⅠⅡ期、初始治疗方案为EFV+3TC+AZT占比最高,有7%的患者最近7d有漏服药物情况。结论福建省AIDS患者经抗病毒治疗后大部分病毒抑制效果较好,对未取得较好抑制效果的个体要加强依从性教育,提高抗病毒治疗成功率,防止HIV耐药的产生。
Objective To understand the virological suppression effect of AIDS patients receiving AIDS virus treatment in Fujian Province and to analyze the epidemiological characteristics and provide the basis for improving the therapeutic effect. Methods Blood samples were collected from AIDS patients receiving antiretroviral therapy for ≥6 months in Fujian Province and HIV-1 viral load was tested. Epidemiological data were collected through the national AIDS integrated management information system to analyze the epidemiological characteristics. Results A total of 3 008 blood samples were detected, of which 2 708 were effectively inhibited by the virus and the inhibition rate was 90.0%. The virus inhibitory effects were different in different areas and at different treatment time points. The virus suppression in Fuzhou, Xiamen and Ningde was better. The treatment time was ≥24 Month virus suppression effect is better. Viral load was not effectively inhibited by men, married or living together, heterosexual transmission, clinical stage â ... ¡, the initial treatment for the highest proportion of EFV + 3TC + AZT, 7% of patients missed the last 7d of drug cases. Conclusion Most AIDS patients in Fujian Province have better anti-viral treatment effect after AIDS virus treatment. Those who do not get better inhibitory effect should strengthen compliance education, improve the success rate of anti-virus treatment and prevent the development of HIV drug resistance.