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目的研究尿毒症患者应用头孢菌素后发生脑病的临床表现,探讨其发病机制、预防及处理。方法分析12例尿毒病患者使用头孢菌素后出现脑病的情况及治疗方法。结果 1、2、3、4代头孢菌素均可引起药物性脑病,并且特点不同,与其药代动力学存在差异有关,停药或透析后均能缓解,无后遗症。结论尿毒症患者应用头孢菌素时需要调整剂量,并高度警惕抗生素致中枢神经系统异常;早期诊断,及时停药并加强血液净化治疗可大大改善临床症状及预后。
Objective To study the clinical manifestations of encephalopathy in patients with uremia after application of cephalosporin and to explore its pathogenesis, prevention and treatment. Methods 12 cases of uremia patients after using cephalosporins encephalopathy and treatment. Results 1,2,3,4 and 4 generations of cephalosporins can cause drug-induced encephalopathy, and different characteristics, and its pharmacokinetic differences exist, can be relieved after stopping or dialysis, no sequelae. Conclusions Uremic patients should adjust dose when using cephalosporins and be highly alert to central nervous system abnormalities caused by antibiotics. Early diagnosis, timely withdrawal and blood purification treatment can greatly improve clinical symptoms and prognosis.