【摘 要】
：
An overwhelming majority of the transcribed genome encodes for non-coding RNA(ncR NA) sequences. Deep sequencing of the transcriptome has uncovered tens of thou
【机 构】
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Department of Biochemistry and Molecular Biology, University of Maryland School of Medicine,
【出 处】
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World Journal of Clinical Oncology
论文部分内容阅读
An overwhelming majority of the transcribed genome encodes for non-coding RNA(ncR NA) sequences. Deep sequencing of the transcriptome has uncovered tens of thousands of long ncR NA(lncR NA) sequences. However, little is known regarding the possible functions for a vast majority of these sequences. Among those lncR NAs whose function has been experimentally validated, most serve as regulators of gene expression. LncR NAs have been found to be critical to development and homeostasis and they have been implicated in several pathologies including cancer. Here, we examine the functions and underlying mechanisms of lnc RNAs in stem cells and in cancer biology, areas linked by the actions of lncR NAs.
An overwhelming majority of the transcribed genome encodes for non-coding RNA (ncR NA) sequences. Deep sequencing of the transcriptome has uncovered tens of thousands of long ncR NA (lncR NA) sequences. However, little is known regarding the possible functions for a Among these lncR NAs whose function has been experimentally validated, most serve as regulators of gene expression. LncR NAs have been found to be critical to development and homeostasis and they have been implicated in several pathologies including cancer. Here, we examine the functions and underlying mechanisms of lnc RNAs in stem cells and in cancer biology, areas linked by the actions of lncR NAs.
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