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本文用亚硝胺类致癌物的前体物—肌氨酸乙酯和亚硝酸钠混合灌喂大鼠,不但能引起食管上皮的增生及癌,同时可见前胃癌的发生,并且癌侵犯肌层、浆膜及远处转移,后者文献未见报导。国产维甲酸衍生物RI,N-(4-乙氧羰基苯基)维甲酰胺,对食管前胃癌变的发生发展均有明显的抑制作用,对照组癌的发生率为81.8％,RI组下降为11.6％,P<0.01。应用网状内皮系统(RES)功能测定,RI对吞噬功能有轻度刺激,但无统计学意义。X光钡餐造影可用于追随大鼠食管癌变过程及显示癌的发生及发展及其所在部位,有助于实验进程的观察。
In this study, rats fed with nitrosamine carcinogen precursors, sarcosine ethyl ester and sodium nitrite, not only can cause hyperplasia and carcinoma of the esophageal epithelium, but also the occurrence of precancerous gastric cancer. , serosa and distant metastasis, the latter literature has not been reported. Domestic retinoic acid derivatives RI, N-(4-ethoxycarbonylphenyl) retinamide had obvious inhibitory effects on the occurrence and development of esophageal precancerous lesions. The incidence of cancer in the control group was 81.8%, and the RI group decreased. It was 11.6%, P<0.01. Using RES function, RI slightly stimulated phagocytosis, but it was not statistically significant. X-ray barium meal imaging can be used to follow the development of esophageal carcinogenesis in rats and show the occurrence and development of cancer and its site, which is helpful for the observation of the experimental process.