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目的：快速建立实验性癫癎动物模型。方法：１７ 只大鼠右侧海马和１１ 只鼠右侧杏仁核均埋植电极，用ＩＳ２ 型智能刺激器，以２００６００ μＡ 电脉冲刺激点燃海马杏仁核。结果：电刺激可诱发癎性发作和后放电，癎性行为分为五级，后放电呈高幅棘波。在点燃过程中，可记录到两种脑电活动：癎性脑电活动和自发性癎性脑电活动。随着电刺激次数的增多，发现Ⅱ、Ⅲ级癎性行为伴随较短的后放电时程，Ⅳ级以上癎性行为伴随较长的后放电时程。对原参数的刺激，大鼠癎性发作的敏感性增强并可持续数周。结论：应用低频短间隔电脉冲刺激大鼠海马或杏仁核可快速建立稳固的动物癫癎模型。
Objective: To establish an experimental animal model of epilepsy rapidly. Methods: The right hippocampus and the right amygdala of 11 rats were implanted with electrodes in 17 rats. The hippocampal amygdala was stimulated by 200 600 μA electrical pulse with IS2 smart stimulator. Results: Electrical stimulation induced seizure and post-discharge, 癎 sexual behavior is divided into five levels, post discharge was high amplitude spikes. During ignition, two types of EEG events can be recorded: 癎 EEG activity and spontaneous 癎 EEG activity. With the increase of the number of electrical stimulation, it was found that Ⅱ, Ⅲ grade 癎 sexual behavior with a short post-discharge time, Ⅳ grade 癎 sexual behavior with a longer post-discharge time. The stimulation of the original parameters, the sensitivity of the rat seizures increased and can last for several weeks. Conclusion: The stimulation of hippocampus or amygdala in rats with low-frequency short-interval electrical stimulation can rapidly establish a stable animal model of epilepsy.