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作者选择了40例晚期食管鳞状细胞癌病人,应用顺氯氨铂、5-氟脲嘧啶及别嘌呤醇行联合化疗。其治疗方案为:别嘌呤醇600mg/天,口服1～7天,顺氯氨铂100mg/m~2/天 iv,2小时内滴完,5-氟脲嘧啶1000mg/m~2/天,iv 连续5天。第22天再重复以上方案。当白细胞<4000/ml、血小板<10万/ml 时暂停化疗,使血象恢复。有效者接受最大量,给6疗程,恶化者则停止化疗。治疗期未给予营养支持。结果:40例病人中,有3例不能评价其效果,每
The authors selected 40 patients with advanced esophageal squamous cell carcinoma and received combination chemotherapy with cisplatin, 5-fluorouracil, and allopurinol. The treatment program is: allopurinol 600mg / day, oral 1 ~ 7 days, cisplatin 100mg/m ~ 2 / day iv, 2 hours to complete, 5-fluorouracil 1000mg/m ~ 2 / day, Iv For 5 consecutive days. Repeat the above program on the 22nd day. When leukocytes <4000/ml, platelets <100,000/ml, chemotherapy was suspended to restore blood. The effective recipients received the maximum amount and gave 6 courses of treatment. The worsened patients stopped chemotherapy. No nutritional support was given during the treatment period. Results: Of the 40 patients, 3 were unable to evaluate their effects.