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“冠心1号”(下简称“冠I”)系来自斑褐孔菌Suscoporia Punctata(Fr.)Cunn的菌丝部分。据本省民间经验,用斑褐孔菌子实体煎服治疗心绞痛有效。为了给初期临床试验提供药理基础,我们进行以下实验。一、对缺氧耐力的影响 (一)减压缺氧耐力试验:取18～24g小鼠40只,雌雄各半,禁食12小时后,随机均匀分成4组。腹腔注射给药,30分钟后,置入负压(500mmHg)的装置中进行试验。结果如右表。
“Guanxin 1” (hereinafter referred to as “crown I”) is derived from the mycelium portion of Succoporia Punctata (Fr.) Cunn. According to the civil experience of the province, it is effective to use the fruit body decoction of the brown blotch to treat angina pectoris. In order to provide the pharmacological basis for the initial clinical trials, we performed the following experiments. First, the impact of hypoxia tolerance (A) decompression and hypoxia tolerance test: Take 18 ~ 24g mice 40, male and female, after fasting for 12 hours, were randomly divided into 4 groups. For intraperitoneal injection, 30 minutes later, the test was performed by placing a device under negative pressure (500 mmHg). The result is shown in the right table.