Natural biomacromolecules have attracted increased attention as carriers in biomedicine in recent years because of their inherent biochemical and biophysical properties including renewability,nontoxicity,biocompatibility,biodegradability,long blood circulation time and targeting ability.Recent advances in our understanding of the biological functions of natural-origin biomacromolecules and the progress in the study of biological drug carriers indicate that such carriers may have advantages over synthetic material-based carriers in terms of half-life,stability,safety and ease of manufacture.In this review,we give a brief introduction to the biochemical properties of the widely used biomacromoleculebased carriers such as albumin,lipoproteins and polysaccharides.Then examples from the clinic and in recent laboratory development are summarized.Finally the current challenges and future prospects of present biological carriers are discussed.