促性腺激素释放激素(gonadotropinreleasinghormone,GnRH)与垂体前叶细胞膜上特异的G蛋白偶联受体(Gproteincoupledreceptor,GPCR)结合,激活胞内一系列信号分子,最终使特定的基因表达,合成并分泌黄体生成素和卵泡刺激素。此外,GnRH脉冲频率的变化可影响胞内信号通路组件和下游基因反应的模式。促性腺激素基因自身结构的差异及各自启动子结构的不同,可部分解释GnRH受体下游基因反应的频率敏感性。 Gonadotropin-releasing hormone (GnRH) binds to a G protein-coupled receptor (GPCR) specific to the anterior pituitary cell membrane and activates a series of intracellular signaling molecules that ultimately allow the expression, synthesis and secretion of specific genes Bursin and follicle stimulating hormone. In addition, changes in GnRH pulse frequency can affect the pattern of intracellular signaling components and downstream gene responses. The difference in the structure of gonadotrophin genes and the differences in their promoter structures can partly explain the frequency sensitivity of downstream GnRH receptor genes.