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目的探讨131I治疗对抗甲状腺药物(ATD)有不良反应的甲亢患者的疗效.方法选择我科收治的63例患者,每克甲状腺组织应给予131I治疗剂量70~120μCi,但特殊患者应给予针对性的131I治疗剂量.结果本组63例患者,131I治疗后临床痊愈51例(80.95%),有效10例(15.87%),无效2例(3.17%),总有效率为96.83%.治疗后1年61例有效患者甲状腺重量明显少于治疗前,差别有统计学意义(p<0.05).发生暂时性甲减8例(12.70%),治疗期间发生不良反应6例(9.52%).结论131I治疗对ATD治疗有不良反应的甲亢患者疗效显著,安全性高,费用低廉,易被患者及医师接受,值得临床广泛推广.“,”Objective: To discuss the clinical effect of reating hyperthyroidism patients intolerant antithyroid drugs with 131I. Methods: Choosed 63 patients, thyroid tissue per gram was treated 131I 70-120μCi, but special patients should be treated with special dose. Results: There were 51 cases cured (80.95%), 10 cases effective (15.87%), 2 cases invalid (3.17%). The total effective rate was 96.83%. The weight of thyroid in 61 cases of effective patients was less than befor after 1 year treatment (P<0.05). There were 8 cases temporary hypothyroidism (12.70%), 6 cases adverse effects (9.52%). Conclusion: Treating hyperthyroidism patients intolerant antithyroid drugs with 131I has significant effect and high safety to extend in clinic.