论文部分内容阅读
LKB1 STK1 1基因是PJS患者的主要致病基因 ,为一种肿瘤抑制基因 ,编码一种功能未知的丝氨酸 苏氨酸蛋白激酶。LKB1基因的失活性表达以低频率事件广泛存在于全身多种肿瘤中 ,并在细胞生长抑制和p53依赖性细胞凋亡 ,以及胚胎和血管发育中具有重要作用
The LKB1 STK1 1 gene is a major causative gene of PJS and is a tumor suppressor gene encoding a serine-threonine protein kinase of unknown function. Inactivating expression of the LKB1 gene is widespread in many tumors throughout the body with low frequency events and plays an important role in cell growth inhibition and p53-dependent apoptosis as well as embryonic and vascular development