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目的观察急性冠脉综合征(ACS)患者基质金属蛋白酶-2(MMP-2)、白介素-18(IL-18)和纤维蛋白原(Fib)的含量变化及意义。方法选择56例ACS患者,其中不稳定心绞痛(UA)32例作为UA组,急性心肌梗死(AMI)24例作为AMI组,稳定性心绞痛36例作为SAP组,健康成人40例作为对照组,采用ELISA法检测ACS患者发病后第1天、第3天和第10天血清中的MMP-2、IL-18浓度,Clauss法检测Fib的浓度,并与对照组进行比较。结果 UA组和AMI组患者血清中MMP-2和IL-18浓度均高于SAP组和对照组﹙P<0.05),Fib浓度无明显差异﹙P>0.05﹚。ACS组患者血清中MMP-2的含量于发病后第1天达到峰值,此后逐渐下降;IL-18在发病后第3天达到峰值。结论 MMP-2和IL-18在ACS的发病过程中起重要作用。
Objective To observe the changes of MMP-2, IL-18 and fibrinogen in patients with acute coronary syndrome (ACS) and its significance. Methods Fifty-six patients with ACS were enrolled. Among them, 32 cases of unstable angina pectoris (UA) were treated as UA group, 24 cases of acute myocardial infarction (AMI) as AMI group, 36 cases of stable angina pectoris as SAP group and 40 healthy adults as control group Serum levels of MMP-2 and IL-18 in serum of ACS patients on day 1, day 3 and day 10 were detected by ELISA. Fib concentrations were measured by Clauss method and compared with that of control group. Results Serum levels of MMP-2 and IL-18 in patients with UA and AMI were significantly higher than those in SAP and control (P <0.05). There was no significant difference in Fib concentrations between UA and AMI patients (P> 0.05). Serum levels of MMP-2 in ACS group peaked on the first day after onset, and then decreased gradually; IL-18 peaked on the third day after onset. Conclusion MMP-2 and IL-18 play an important role in the pathogenesis of ACS.