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为研究热休克蛋白 6 0 (HSP6 0 )在人胃癌组织中的表达 ,对 6 0例非癌胃粘膜病变和 5 0例胃癌组织手术、胃镜活检石蜡标本 ,应用免疫组织化学方法检测 HSP的表达。结果显示 :HSP6 0在肠上皮化生、不典型增生及胃癌中的阳性率和过表达率均明显高于慢性浅表性胃炎 (P <0 .0 5 ) ;在胃癌组织中的过表达率高于肠上皮化生和不典型增生 (P <0 .0 5 )。HSP6 0在不同分化程度胃癌中表达无明显差异 (P >0 .0 5 ) ;在胃癌组织的过表达率高于肠上皮化生和不典型增生 (P <0 .0 5 )。 HSP6 0在不同分化程度胃癌中表达无明显差异 (P >0 .0 5 )。结果表明 ,HSP6 0在人胃癌、癌前情况和病变中过度表达可能与胃癌的发生、发展有关。
In order to study the expression of heat shock protein 60 (HSP60) in human gastric cancer tissues, 60 cases of non-cancerous gastric mucosal lesions and 50 cases of gastric cancer tissues and gastroscope biopsies were detected by immunohistochemistry . The results showed that the positive rate and overexpression rate of HSP60 in intestinal metaplasia, atypical hyperplasia and gastric cancer were significantly higher than those in chronic superficial gastritis (P <0.05). The overexpression rate of HSP60 in gastric cancer Higher than intestinal metaplasia and dysplasia (P <0.05). There was no significant difference in the expression of HSP60 among gastric cancer tissues with different degrees of differentiation (P> 0.05). The overexpression rate of HSP60 in gastric cancer tissue was higher than that in intestinal metaplasia and dysplasia (P <0.05). There was no significant difference in the expression of HSP60 in gastric cancer with different differentiation (P> 0.05). The results showed that HSP60 expression in human gastric cancer, precancerous conditions and lesions may be related to the occurrence and development of gastric cancer.