肝纤维化是肝脏细胞外基质(ECM)异常生成和积累的结果,肝星状细胞(hepatic stellate cells,HSC)为肝纤维化形成的关键细胞。HSC在诸多因素(如细胞因子、生长因子、肝细胞、Kupffer细胞、内皮细胞等)的调控下,HSC持续激活导致胶原生成细胞增多,并最终引起ECM的大量沉积,同时在肝纤维化的逆转过程中,HSC的减少主要通过凋亡机制。因此HSC的激活增殖是各种原因引起肝纤维化形成的中心环节,阻抑激活的HSC增殖和诱导其凋亡是治疗慢性 Hepatic fibrosis is a result of abnormal production and accumulation of extracellular matrix (ECM) in the liver, and hepatic stellate cells (HSCs) are the key cells for the formation of hepatic fibrosis. HSC under the control of many factors (such as cytokines, growth factors, hepatocytes, Kupffer cells, endothelial cells, etc.), continued activation of HSC lead to collagen-producing cells increased and eventually lead to a large deposition of ECM, while reversal of liver fibrosis During the process, the reduction of HSC mainly through the apoptosis mechanism. Therefore, the activation of HSC proliferation is caused by various reasons, the central link in the formation of liver fibrosis, inhibition of activated HSC proliferation and induction of apoptosis is the treatment of chronic