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Objective:To explore the expression of mdr-1, multidrug resistance asso-ciated protein(MRP)and lung resistance protein(LRP) genes in human gastric Gancer andtheir Glinical significance. Methods:The mdr-1 mRNA was assayed by RT-PCR, the MRPand LRP were detected by flow cytometry. Results:The positive rate of mdr-1 mRNA is44.4%(12/27), and the mean MRP and LRP expression rate is 39.1% and 29.9%, respec-tively. The mdr-1 mRNA, MRP or LRP expression is independent of patient histologic type,nodal involvement, and TNM stage. The mdr-1 mRNA expression in patients with serosa in-vasion was 30.0% (6/20),much lower than that without serosa invasion (85.7%).Con-clusion:The multidrug resistance cells are present in primary gastric carcinomas priorto chemotherapy and analysis of mdr-1 gene, MRP, LRP may have guiding significance inthe treatment of gastric carcinoma.
Methods: The mdr-1 mRNA was assayed by RT-PCR. The MRPand LRP were detected by flow cytometry. Results:The positive rate of mdr-1 mRNA is 44.4%(12/27), and the mean MRP and LRP expression rate is 39.1% and 29.9%, respec-tively. The mdr -1 mRNA, MRP or LRP expression is independent of patient histologic type, nodal involvement, and TNM stage. The mdr-1 mRNA expression in patients with serosa in-vasion was 30.0% (6/20), much lower than that without serosa Invasion (85.7%). Con-clusion: The multidrug resistance cells are present in primary gastric carcinomas priorto chemotherapy and analysis of mdr-1 gene, MRP, LRP may have guiding significance in the treatment of gastric carcinoma.