【摘 要】
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Influenza virus is a long-lasting and severe threat to human health.Seasonal flu epidemics,which are caused by the cocirculating influenza A viruses (IAVs) and
【机 构】
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CAS Key Laboratory of Pathogenic Microbiology and Immunology, Institute of Microbiology, Chinese Aca
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Influenza virus is a long-lasting and severe threat to human health.Seasonal flu epidemics,which are caused by the cocirculating influenza A viruses (IAVs) and influenza B viruses (IBVs),occur annually and lead to tens of millions of respiratory illnesses and up to half a million human deaths worldwide each year (Ginsberg et al.,2009).Influenza pandemics are more devastating.The 2009 swine-originated H1N1 virus,which caused the latest influenza pandemic,spread from Mexico and U.S.to virtually all countries throughout the world within only several months and was associated much higher mortality among children,young adults,and pregnant women than typical seasonal influenza viruses (Fineberg,2014).The zoonotic avian influenza viruses,including H5N1,H5N6,H7N9 and H10N8,cause alarmingly high fatality rate in human cases,raising a public concem of pandemic influenza outbreak of avian origin (Poovorawan et al.,2013;Barr,2017;Bui et al.,2017).
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