Objective:To determine the clinical characteristics,diagnosis and treatment of genital human papillomavirus(HPV) infection in the pregnant women and whether a woman with persistent HPV infection may get pregnant or not. Methods:Forty-five patients with genital HPV infection during pregnancy attending this hospital were analyzed retrospectively. Results:Among forty-five patients with genital HPV infection,26(58%) had genital warts,18(38%) had pathological changes but no symptoms and 1(4%) was in a latent infection checked by HPV-DNA without symptom and pathological changes.10(22%) patients had other genital infections simultaneously.Only 16 (36%) of the patients had undergone the treatment of drug,laser,cryosurgery or surgery.39 patients,including 3 patients with persistent HPV infection,had a full-term pregnancy.No respiratory papillomatosis cases were identified in any infants.In follow-up,3 patients still had genital warts.13 patients had thinprep cytologic test again and the results of 4 patients were abnormal.5 patients had hybrid capture(HC2) again and 2 were positive. Conclusion:Respiratory papillomatosis cases were rare in the children with a maternal history of genital HPV infection during pregnancy.Pregnant women with genital HPV infection often had other genital infections.The patients with persistent HPV infection may try to get pregnant when virus burden is low. Objective: To determine the clinical characteristics, diagnosis and treatment of genital human papillomavirus (HPV) infection in the pregnant women and whether a woman with persistent HPV infection may get pregnant or not. Methods: Forty-five patients with genital HPV infection during pregnancy attended had (4%) was in a latent infection checked (1) Results: Among forty-five patients with genital HPV infection, 26 (58%) had genital warts, 18 by HPV-DNA without symptom and pathological changes. 10 (22%) patients had other genital infections simultaneously. Only 16 (36%) of the patients had undergone the treatment of drug, laser, cryosurgery or surgery. 39 patients, including 3 patients with persistent HPV infection, had a full-term pregnancy. No respiratory papillomatosis cases were identified in any infants. In follow-up, 3 patients still had genital warts. 13 patients had thinprep cytologic test again and the results of 4 patients were abnormal.5patients had hybrid capture (HC2) again and 2 were positive. Conclusion: Respiratory papillomatosis cases were rare in the children with a maternal history of genital HPV infection during pregnancy. Pregnant women with genital HPV infection often had other genital infections.The patients with persistent HPV infection may try to get pregnant when virus burden is low.