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目的了解血吸虫病脾脏厚度与肝纤维化程度的相关性,探讨应用无创性的检查方法来评估血吸虫病肝纤维化的程度。方法收集169例血吸虫病患者脾脏切除和术中肝活检组织标本,测量脾脏厚度(SPT),应用苦味酸天狼猩红特殊染色,对肝组织进行纤维化分期诊断。结果血吸虫病肝纤维化S1～S4期对应的脾脏厚度分别为(54.7±4.9)、(56.6±6.4)、(63.8±10.5)、(70.4±16.3)mm,S1～S4期脾脏逐渐增厚;肝纤维化S3或S4期与S1或S2期之间的脾脏厚度有显著性差异(P<0.05)。结论脾脏厚度对诊断血吸虫病患者肝纤维化程度有一定的参考价值。
Objective To understand the correlation between the thickness of spleen and the degree of liver fibrosis in schistosomiasis and to evaluate the extent of liver fibrosis in schistosomiasis by noninvasive methods. Methods Totally 169 cases of schistosomiasis patients were collected for spleen resection and intraoperative liver biopsy. Spleen thickness (SPT) was measured. The picric acid Sirius Red staining was used to diagnose liver fibrosis stage. Results The spleen thickness of S1 ~ S4 in schistosomiasis patients were (54.7 ± 4.9), (56.6 ± 6.4), (63.8 ± 10.5) and (70.4 ± 16.3) mm, respectively. There was a significant difference in the thickness of spleen between S3 or S4 and S1 or S2 of liver fibrosis (P <0.05). Conclusion The thickness of spleen has certain reference value for the diagnosis of liver fibrosis in patients with schistosomiasis.