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目的探讨白细胞介素－5（IL－5）、可溶性白细胞介素－2受体（sIL－2R）、一氧化氮（NO）及嗜酸性粒细胞（EOS）在哮喘发病中的意义。方法对治疗前后的急性发作期、稳定期哮喘组及对照组血清IL－5、sIL－2R和NO水平及EOS计数进行了研究。结果哮喘急性发作组血清IL-5、sIL－2R、NO及EOS水平均明显高于哮喘缓解期组与对照组。哮喘发作期IL－5与EOS呈显著正相关。哮喘息性发作期组治疗后sIL－2R及NO水平较治疗前显著降低，IL－5与EOS水平下降但无统计学意义。结论血清IL－5、sIL－2R、NO及EOS水平升高，与哮喘发作密切相关。
Objective To investigate the significance of interleukin-5 (IL-5), soluble interleukin-2 receptor (sIL-2R), nitric oxide (NO) and eosinophil (EOS) in the pathogenesis of asthma. Methods Serum levels of IL-5, sIL-2R and NO as well as EOS counts in acute asthma group and control group were measured before and after treatment. Results Serum levels of IL-5, sIL-2R, NO and EOS in patients with acute asthma were significantly higher than those in patients with remission and control. There was a significant positive correlation between IL-5 and EOS during asthma attack. The levels of sIL-2R and NO in patients with asthma exacerbation group were significantly lower than those before treatment, while the levels of IL-5 and EOS were decreased but not statistically significant. Conclusion Serum levels of IL-5, sIL-2R, NO and EOS are elevated, which are closely related to asthma attacks.