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目的：研究重组人白介素－１α（ＩＬ－１）对大鼠微血管白细胞的滚动与粘附作用。方法：采用高倍显微电视放大技术观察大鼠脊斜肌微循环标本白细胞的变化。结果：ＩＬ－１（０．１２５～０．７５ｍｇ·ｋｇ－１）ｉｐ后显著促进微血管中白细胞的滚动与粘附，有明显的量效关系。白细胞的滚动在给药（０．５ｍｇ·ｋｇ－１）３ｍｉｎ后从正常４±１增至７８±９．０个·ｍｉｎ－１。粘附于微血管壁的白细胞在ＩＬ－１给药３０ｍｉｎ后，从正常每８０μｍ血管１．０±１．０增至１４．０±３．０个。结论：ＩＬ－１促进大鼠脊斜肌微循环中的白细胞滚动与粘附。
Objective: To investigate the effect of recombinant human interleukin-1α (IL-1) on the rolling and adhesion of rat microvascular leucocytes. Methods: High magnification microscopic TV amplification was used to observe the changes of white blood cells in rat spine oblique microcirculation specimens. Results: IL-1 (0.125-0.75 mg · kg-1) ip significantly promoted the leukocyte rolling and adhesion in microvessels with a significant dose-response relationship. The leukocyte rolling increased from normal 4 ± 1 to 78 ± 9.0 min-1 after 3 min of administration (0.5 mg · kg -1). Leukocytes adhered to the microvascular wall increased from 1.0 ± 1.0 to 14.0 ± 3.0 from normal for each 80 μm vessel 30 min after IL-1 administration. Conclusion: IL-1 promotes leukocyte rolling and adhesion in the spina bifida muscle in rats.