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Unbalanced economic growth is a ubiquitous phenomenon while investigating the regional development at a large spatial scale.Therefore,it is of great significance to analyze the spatio-temporal pattern of regional economic growth and the drivers to understand and facilitate the economic development of low development areas.Taking a county as a funda-mental study unit,we used the county-level per capita GDP data on the Loess Plateau from 2005 to 2017,and geographic variables such as slope,elevation,and population density to analyze the spatio-temporal differences and the driving factors of the county-level economic development in the Loess Plateau by employing both conventional and advanced quantitative methods including Exploratory Spatial Data Analysis(ESDA)and the geographic detector model.Our results suggested that:(1)The selected indicators,including absolute difference,the fluctuation of relative difference and total difference of economic development on the Loess Plateau,all show steady increasing trends,respectively.(2)There are 64.5％of the counties with economic development being below the average level of the whole Loss Pla-teau region.The relatively high developed counties are distributed in the“A”-shaped regions in Inner Mongolia Autonomous Region,Shaanxi,and Henan provinces,however,the low development counties are mainly located in the“V”-shaped regions in Gansu and Shanxi provinces.(3)GDP,investment in fixed assets and urbanization rate are the major driving factors influencing the regional economic development,and the combined effects are far greater than that of any individual factor.