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二丙基醋酸钠(Divalproex sodium)和丙戊酸(Valproic acid)作为抗惊厥药已广泛使用25年,严重副作用少见。9～22%的患者可出现胃肠不适如厌食、消化不良、胃灼热、恶心,偶而呕吐和腹泻。有报告85%的患者对消化道不适可逐渐耐受。慢性或晚发性胃肠道不适尚无报告,本文描述10例长期用药和完全耐受药物后发生胃炎的患儿。作者先从癫痫患者随访中发现2例糜烂性胃炎患儿。随后回顾1986年1月～1987年3月经内窥镜或活组织检查证实为糜烂性胃炎的病例,发现5例类似的患儿。在门诊随访中又发现3例。其中9例
Divalproex sodium and valproic acid have been widely used as anticonvulsants for 25 years with few serious side effects. 9-22% of patients may experience gastrointestinal upset such as anorexia, dyspepsia, heartburn, nausea, occasional vomiting and diarrhea. 85% of patients have reported gradual tolerance of gastrointestinal discomfort. Chronic or late gastrointestinal discomfort is still not reported, this article describes 10 cases of chronic gastritis and chronic drug-resistant children. The authors first found 2 cases of erosive gastritis in children with epilepsy. Then reviewed January 1986 ~ March 1987 by endoscopy or biopsy confirmed as erosive gastritis cases and found 5 similar cases of children. In the clinic follow-up found in 3 cases. Of which 9 cases