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过去作胃液分析,常采用面包餐、酒精或磷酸组织胺作为泌酸刺激剂,由于其泌酸作用微弱或不能精确反应泌酸功能。以及副作用严重等原因,近年来已为五肽胃泌素所替代。胃泌素是胃窦部粘膜分泌的一种17肽激素,具有促使胃的壁细胞分泌盐酸的生理作用。在胃泌素的分子结构中,C端的四肽具有胃泌素的全部生理作用,四肽的顺序是色氨酸-甲硫氨酸-门冬氨酸-苯丙氦酸-氨基。五肤胃泌素系人工合成,由胃泌素C端的四肽加上一个β-丙氯酸即成。它具有胃泌素的全部生理特性,英国ICI厂于1966
In the past for gastric fluid analysis, often using bread meal, alcohol or histamine phosphate as acid stimulants, because of its acid secretion or can not accurately reflect the acid secretion. As well as serious side effects and other reasons, in recent years has been replaced by pentagastrin. Gastrin is a 17-peptide hormone secreted by gastric mucosa of gastric antrum and has the physiological function of promoting the secretion of hydrochloric acid by gastric parietal cells. In the molecular structure of gastrin, the C-terminal tetrapeptide has the full physiological effect of gastrin and the tetrapeptide sequence is tryptophan-methionine-aspartate-phenylpropionate-amino. Five skin gastrin synthesis, composed of gastrin C-terminal tetrapeptide plus a β-propionic acid Serve. It has all the physiological properties of gastrin, the British ICI plant in 1966