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为探讨阿米巴在宿主体内增强致病力的机制,作者研究了提高组胺和乙酰胆碱水平对7株溶组织内阿米巴毒力的影响。试验所用动物为刚断奶的大鼠,体重25～30g。阿米巴系从非阿米巴性结肠炎病人粪便(4株)和无症状排包囊者粪便(3株)分离而得,在改良的Boeck和Drobhlav氏培养基连续培养维持生长。每株阿米巴按作者以前描述的方法接种于大鼠盲肠内。分试验组和对照组,每组10只。感染后7天将鼠处死,根据Neal标准检查
In order to investigate the mechanism of amoebic enhancing virulence in the host, the authors investigated the effect of increasing histamine and acetylcholine levels on the virulence of the seven strains of Entamoeba histolytica. Animals used in the experiment were just weaned rats weighing 25-30 g. Amoeba was isolated from feces of non-amebic colitis patients (4 strains) and asymptomatic placenta builders (3 strains), and was maintained in continuous culture in modified Boeck’s and Drobhlav’s media. Each amoeba was inoculated into the rat cecum according to the method previously described by the author. Sub-test group and control group, 10 rats in each group. The mice were sacrificed 7 days after infection and examined according to Neal criteria