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目的比较不同的急性心肌梗死(简称心梗)造模方法导致室性心律失常发生的差异,探索最佳造模方法。方法 45只苏中幼猪随机分为假手术组(Sham组,n=5)、开胸结扎左前降支(LAD)组(结扎组,n=17)和经导管球囊封堵LAD组(封堵组,n=23)。结扎/封堵后90 min内心电图监测动物室性心律失常发生情况。饲养8周后,以2,3,5-氯化三苯基四氮唑(TTC)染色、HE染色鉴定梗死模型是否成功。结果与结扎组相比,封堵组术后即刻存活率低(60.87%vs 94.12%,P<0.05),室性早搏、室性心动过速的发生率没有明显差异(91.30%vs 70.59%,30.43%vs 29.41%;P均>0.05);但封堵组心室颤动发生率明显增高(69.57%vs 5.88%,P<0.001)。8周后经TTC、HE染色鉴定,两组造模成功率无显著差异(68.75%vs 92.86%,P=0.234),但是封堵组梗死面积较大。结论与结扎法相比,封堵法可以导致大面积心梗,室性心律失常发生率高。
Objective To compare the differences in the occurrence of ventricular arrhythmias between different acute myocardial infarction (MI) modeling methods and to explore the best modeling method. Methods Forty-five young piglets were randomly divided into four groups: Sham group (n = 5), LAD group (n = 17) and LAD group Blocking group, n = 23). Electrocardiographic monitoring of ventricular arrhythmias within 90 min after ligation / occlusion. After 8 weeks of feeding, infarction models were successfully identified by staining with 2,3,5-triphenyltetrazolium chloride (TTC) and HE staining. Results Compared with the ligation group, the survival rate immediately after closure in the occlusion group was significantly lower (60.87% vs 94.12%, P <0.05), while there was no significant difference in the incidence of ventricular premature beat and ventricular tachycardia (91.30% vs 70.59% 30.43% vs 29.41%, P> 0.05). However, the incidence of ventricular fibrillation in the occlusion group was significantly higher (69.57% vs 5.88%, P <0.001). After 8 weeks, TTC and HE staining showed that there was no significant difference in success rate between the two groups (68.75% vs 92.86%, P = 0.234). However, infarction area was larger in the occlusion group. Conclusion Compared with the ligation method, blocking method can lead to large-scale myocardial infarction, ventricular arrhythmia incidence.