目的　探讨在黄体期无保护性生活后 ,使用米非司酮配伍米索前列醇避孕的效果、副反应和对月经的影响。方法　对因多次无保护性生活或无保护性生活结束超过 12 0h要求紧急避孕的69 9例妇女 ,于预期月经来潮前 10d内服用米非司酮 10 0mg ,并于服用米非司酮 48h后加服米索前列醇 40 0 μg。观察是否妊娠和下次月经的情况。 结果　 699例妇女中失访 1例 ,妊娠 2 5例 ,妊娠率 (即失败率 )为 3 6%。妊娠危险性随性生活次数的增多而增加。 673例妇女月经来潮 ,其中 3 81例( 56 6% )在预期月经日± 3d来潮 ,月经提前或延迟超过 7d者分别占 2 2 %和 8 5%。服药后 1周内的主要副反应为腹泻、腹痛 ( 3 1 1% )和恶心、呕吐 ( 2 0 4% )。结论　在黄体期使用米非司酮配伍米索前列醇 ,是一种可选择的避孕补救方法 Objective To investigate the effects of side effects and side effects of mifepristone and misoprostol on menstruation after unprotected luteal phase. Methods 699 women who required emergency contraception after multiple unprotected or unprotected life ended more than 120 hours were given mifepristone 10 mg within 10 days prior to expected menstrual flow and were given mifepristone 48 h After adding misoprostol 40 0 ​​μg. Observe whether the pregnancy and the next menstrual situation. Results Among the 699 women lost in 1 case and 25 in pregnancy, the pregnancy rate (or failure rate) was 36%. Pregnancy risk increases with the increase in the number of sexual life. Among the 673 women who had menstrual cramps, 3 81 (56.6%) had a craze of ± 3d on the expected menstrual day and 22% and 85% of the women had advanced or delayed more than 7 days respectively. The main side effects within 1 week after taking the medication were diarrhea, abdominal pain (31.1%) and nausea and vomiting (20%). Conclusions The use of mifepristone in combination with misoprostol in the luteal phase is an alternative contraceptive remedy