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目的 探讨新生儿缺氧缺血性脑病(HIE)时白细胞介素-6(IL-6)、血清淀粉样蛋白A(SAA)、C-反应蛋白(CRP)水平变化及意义。方法 用ELISA法检测40例HIE患儿急性期和恢复期血清IL-6、SAA、CRP水平,并与20例无窒息及感染的新生儿比较。结果HIE轻、中、重三组IL-6、SAA、CRP水平均明显高于对照组,其中重度HIE存活者多数高于其它各组而死亡组均明显低于各治疗组,恢复期三指标均显著下降。SAA恢复较IL-6、CRP缓慢并与。HIE预后有关。结论 同时检测血清IL-6、SAA、CRP水平及变化,对新生儿HIE的早期诊断及对病程、预后的评价具有重要的临床意义。
Objective To investigate the changes and significance of interleukin-6 (IL-6), serum amyloid A (SAA) and C-reactive protein (CRP) in neonates with hypoxic-ischemic encephalopathy (HIE) Methods Serum levels of IL-6, SAA and CRP in 40 HIE children at acute and convalescent stages were detected by ELISA. The levels of serum IL-6, SAA and CRP were compared with 20 non-asphyxiated and infected neonates. Results The levels of IL-6, SAA and CRP in the HIE mild, moderate and severe groups were significantly higher than those in the control group. The majority of severe HIE survivors were significantly higher than those in other groups and the death groups were significantly lower than those in the other three groups All decreased significantly. SAA restored more than IL-6, with CRP slowly and with. HIE prognosis. Conclusion Simultaneous detection of serum IL-6, SAA, CRP levels and changes in the early diagnosis of neonatal HIE and the evaluation of course and prognosis have important clinical significance.