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目的 :研究卡氮芥脂质体 ( BL)对鼠 C6胶质细胞瘤的化疗作用。方法 :30只 Wistar大鼠做实验动物 ,C6胶质细胞脑内移植建立鼠 C6胶质细胞瘤模型、卡氮芥脂质体肿瘤内注射 ,观察化疗作用。结果 :BL组与氯乙亚硝脲 ( BCNU)组存活期存在统计学差异 ( P<0 .0 5)。 BL组与空白对照组存在显著性差异 ( P<0 .0 1 ) ,BCNU组与空白组存在显著性差异 ( P<0 .0 1 )。结论 :BL脑肿瘤内注射 ,控制 BCNU的释放 ,提高 BCNU的药效 ,有效延长荷瘤鼠的存活期。
Objective: To study the chemotherapy effects of cardamine mustard liposomes (BL) on murine C6 glioma. METHODS: Thirty Wistar rats were used as experimental animals. C6 glial cells were transplanted intracerebrally to establish a mouse model of C6 glioma and carda nitrogen mustard liposomes were injected intratumorally to observe the effect of chemotherapy. Results: There was a statistically significant difference in survival between BL and BCNU groups (P<0.05). There was a significant difference between the BL group and the control group (P<0.01), and there was a significant difference between the BCNU group and the blank group (P<0.01). Conclusion :Intracerebral tumor injection of BL controls the release of BCNU, improves the efficacy of BCNU, and effectively prolongs the survival of tumor-bearing mice.