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目的:了解合并糖耐量异常的中年部队干部体脂含量及分布特点,探讨成人体脂分布与胰岛素抵抗的关系。方法:选择中年部队干部共203例,采集人体学参数,进行口服葡萄糖耐量试验(OGTT)、胰岛素释放试验(IRT),根据OGTT结果将体检干部分为糖耐量异常(IGT)组和正常(NGT)组,利用生物电阻抗分析法测量体脂分布。结果:BMI、腰围、腰臀比、体脂率、内脏脂肪面积、腹部肥胖程度与空腹胰岛素、胰岛素抵抗指数呈正相关。IGT组体质指数、体脂率、肥胖程度、腹部肥胖阶段、腰围、腰臀比、糖化血红蛋白、空腹血糖、糖后1 h血糖、糖后2 h血糖、空腹胰岛素、糖后1h胰岛素、糖后2 h胰岛素、胰岛素抵抗指数均高于对照组,多元逐步回归分析显示:HOMA-IR的主要影响因素为腰臀比、内脏脂肪面积。结论:内脏脂肪面积是导致胰岛素抵抗的主要因素。
OBJECTIVE: To understand the body fat content and distribution characteristics of middle-aged army cadres with impaired glucose tolerance and to explore the relationship between body fat distribution and insulin resistance in adults. Methods: A total of 203 middle-aged military cadres were selected to collect anthropometric parameters for oral glucose tolerance test (OGTT) and insulin release test (IRT). According to the OGTT results, the physical examination cadres were divided into IGT group and normal NGT) group, the body fat distribution was measured by bioelectrical impedance analysis. Results: BMI, waist circumference, waist - hip ratio, body fat percentage, visceral fat area and abdominal obesity were positively correlated with fasting insulin and insulin resistance index. Body mass index, body fat percentage, degree of obesity, abdominal obesity, waist circumference, waist-to-hip ratio, glycosylated hemoglobin, fasting blood glucose, glucose 1 h after glucose, glucose, fasting insulin, insulin 1 h 2 h insulin, insulin resistance index were higher than the control group, multivariate stepwise regression analysis showed that: HOMA-IR main factors affecting the waist-hip ratio, visceral fat area. Conclusion: Visceral fat area is the main factor leading to insulin resistance.