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目的:比较正常人和原发性青光眼患者不同分区的多焦视觉诱发电位(multifocalvisualevokedpoten-tial,mfVEP),评价mfVEP在青光眼诊断中的作用。方法:采用法国VisionMonitor多焦视觉电生理仪的二阶kernel技术检测21例32只正常对照眼、37例58只原发性青光眼的mfVEP,将青光眼mfVEP振幅均方根(rootmeansquare,RMS)及潜伏期与正常对照眼行不同分区的比较。结果:正常眼mfVEP的RMS值个体间变异大(变异系数CV=43.05%)。青光眼mfVEP的RMS值在上下半视野,鼻上、颞上、鼻下、颞下四个象限及各个环形分区均较正常对照眼小,且在0～10°环形区域及鼻上象限差异有显著性意义(P<0.05),二者各个区域的潜伏期无差异。结论:正常人mfVEP个体间变异性大;青光眼患者mfVEP振幅较正常人下降,且在中央区域及鼻上象限更为显著。
OBJECTIVE: To compare the multifocal visualevoked potential-tial (mfVEP) between different regions of normal and primary glaucoma and to evaluate the role of mfVEP in the diagnosis of glaucoma. Methods: The mfVEP of 21 patients with 32 normal controls and 37 patients with primary glaucoma was detected by the second-order kernel technology of VisionMonitor Multi-focal Vision Electrophysiology in France. The root mean square (RMS) of mfVEP amplitude and latency Compared with the normal control eye line different partition. Results: The RMS of mfVEP in normal eyes varied greatly between individuals (CV = 43.05%). The RMS values of mfVEP in glaucoma were smaller than those in the control eyes in upper and lower half visual fields, nasal, superior temporal, nasal, and inferior temporal quadrant, and in all annular regions, and there was significant difference in the annular region between 0-10 ° and nasal quadrant (P <0.05), there was no difference in latency between the two regions. CONCLUSION: The variability of mfVEP in normal individuals is high. The amplitude of mfVEP in glaucoma patients is lower than that in normal subjects, and more significantly in the central and nasal quadrant.