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目的 观察脑梗死患者血清碱性成纤维细胞生长因子 (bFGF)的含量变化 ,探讨其在脑梗死发生发展过程中的作用和意义。方法 采用酶联免疫吸附法 (ELISA)检测 5 5例脑梗死患者、 32例其他疾病对照组和 30例正常健康对照组的血清bFGF含量。结果 (1 )脑梗死患者血清bFGF含量较两组对照组显著升高。 (2 )脑梗死患者血清bFGF含量变化与梗死灶大小关系密切 ,而与血脂水平及高血压关系不密切。结论 (1 )监测脑梗死患者血清bFGF含量变化有助于判断病灶大小。 (2 )外源性bFGF治疗对脑梗死具有重要意义。
Objective To observe the change of serum basic fibroblast growth factor (bFGF) in patients with cerebral infarction and to explore its role and significance in the occurrence and development of cerebral infarction. Methods Serum bFGF levels were measured by enzyme-linked immunosorbent assay (ELISA) in 55 patients with cerebral infarction, 32 patients with other diseases and 30 healthy controls. Results (1) Serum bFGF levels in patients with cerebral infarction were significantly higher than those in the two control groups. (2) The serum bFGF content in patients with cerebral infarction is closely related to the size of the infarct, but not to the blood lipid level and hypertension. Conclusion (1) The monitoring of serum bFGF levels in patients with cerebral infarction help to determine the size of the lesion. (2) exogenous bFGF treatment of cerebral infarction is of great significance.