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1 病例报告患者,女,47岁。发现左乳肿物1年于1997—03—18就诊。查体:左乳头下触及一无痛性韧性肿物,直径约3 cm,界限清楚,活动度尚好。门诊诊断:乳腺纤维腺瘤。作肿瘤切除。病理活检:灰白色近圆形肿物,2.5 cm×2.0 cm×1.5 cm,有包膜,切面实性,灰白色,质硬。无明显出血和坏死。镜下见:肿瘤细胞被纤维条索间质分隔呈腺泡状、巢状、条索状排列,腺腔内外见大量嗜酸性分泌物。瘤细胞胞质丰富,透明,淡染,核小圆,居中或偏位,核仁明显,无明显异型性,核分裂少见。PAS抗淀粉酶染色阳性(附图)。免疫组化标记:雌、孕激素受体阴性。病理诊断:乳腺分泌型癌。
1 case report patient, female, 47 years old. The left breast mass was found 1 year in 1997-03-18. Physical examination: A painless tough mass was touched under the left nipple, with a diameter of about 3 cm. The boundary was clear and the activity was still good. Outpatient diagnosis: Breast fibroadenoma. For tumor resection. Pathological biopsy: gray and white near-circular mass, 2.5 cm × 2.0 cm × 1.5 cm, enveloped, solid cut surface, gray, hard. No significant bleeding and necrosis. See under the microscope: The tumor cells were separated by fibroin stroma and were arranged in alveolar, nest, and cord-like structures. Inside and outside the glandular cavity, a large number of eosinophilic secretions were seen. Tumor cells are abundant in cytoplasm, transparent, lightly stained, with small round circles, centered or deviated, and obvious nucleoli, no obvious abnormality, and rare nuclear division. PAS stained positive for amylase (drawings). Immunohistochemical markers: female and progesterone receptors are negative. Pathological diagnosis: breast secretory cancer.