论文部分内容阅读
本文报道一组法国血友病病人 AIDS 病毒(LAV)抗体的研究情况。患者与方法作者研究49例血友病包括甲型 41、乙型8例,并与50名健康男性(46名成人,4名儿童)作对照。病员中无1例患 AIDS 或属于其它AIDS 高危组。这些患者治疗所需的全部凝血因子来自法国大城市的健康志愿献血者。血友病患者和献血员的 LAV 抗体的检测,采用酶联免疫吸附法。对38例甲型血友病患者分别进行了总淋巴细胞、T 淋巴细胞、辅助 T 细胞、抑制 T 细胞以及血清 IgG、IgA和 IgM 水平的检测。结果所有健康献血员 LAV 血清试验阴性。10例(20.4%)血友病的血清抗体试验阳性,其中甲型9例(21.9%),乙型1例(12.5%)。在本研究前2年内未接受任何浓缩因子治疗的11例(甲型8例、
This article reports the development of a panel of AIDS virus (LAV) antibodies in hemophilia patients in France. Patients and Methods The authors studied 49 cases of haemophilia including 41 cases of type A and 8 cases of type B, and compared them to 50 healthy males (46 adults, 4 children). None of the patients had AIDS or were at high risk for other AIDS. All of the clotting factors needed for the treatment of these patients came from healthy volunteer blood donors in large French cities. Detection of LAV antibodies in hemophiliacs and blood donors was performed using enzyme-linked immunosorbent assay. 38 cases of hemophilia A were detected in total lymphocytes, T lymphocytes, helper T cells, T cells and serum IgG, IgA and IgM levels. Results All healthy blood donors tested negative for LAV serum. In 10 cases (20.4%) hemophilia, the serum antibody test was positive, including 9 cases (21.9%) of type A and 1 (12.5%) of type B. In the first 2 years of this study did not receive any enrichment factor treatment in 11 cases (8 cases of type A,