牛黄解毒片(丸)的主要作用是解毒,但如果使用不当却可以导致中毒,临床应用时应注意。在其配方中,大黄、黄芩、桔梗、甘草、生石膏虽然用量较大,但它们毒性较低;牛黄、冰片毒性亦较低,且用量较小。惟有雄黄毒性最强,用量大,其主要成分硫化砷,含砷约75%,含硫为24.9%,遇热易于分解氧化,变成有剧毒的三氧化二砷,即俗称的砒霜,其毒害作用可影响到神经系统、消化系统和泌尿系统等,少 The main role of Niuhuang Jiedu Tablets (Pills) is detoxification, but if used improperly it can lead to poisoning, and clinical application should pay attention. In its formulation, rhubarb, astragalus, platycodon grandiflorum, licorice, and raw gypsum have a relatively low toxicity although they are used in large amounts; bezoar and borneol are also low in toxicity and have a small amount. Only realgar has the strongest toxicity and high dosage. Its main component is arsenic sulfide, which contains about 75% arsenic and 24.9% sulphur. It easily decomposes and oxidizes when exposed to heat and turns into highly toxic arsenic trioxide, commonly known as arsenic trioxide. Affects nervous system, digestive system and urinary system, etc.